讲座题目：Biomimetic Metal-Oxygen Intermediates in Dioxygen Activation Chemistry
讲座人：Wonwoo Nam教授 韩国梨花女子大学化学与纳米科学学部（Department of Chemistry and Nano Science, Ewha Womans University, Korea）
Wonwoo Nam received his B.S. (Honours) degree in Chemistry from California State University, Los Angeles, and his Ph.D. degree in Inorganic Chemistry from University of California, Los Angeles (UCLA) under the supervision of Professor Joan S. Valentine in 1990. After working as a postdoctoral researcher at UCLA for one year, he became an Assistant Professor at Hong Ik University in 1991. In 1994, he moved to Ewha Womans University, where he is currently a Distinguished Professor. His current research is focused on O2 activation, water oxidation, metal-oxygen intermediates, such as metal-oxo, meta-superoxo, metal-peroxo and metal-hydroperoxo species, and important roles of metal ions in biological reactions.
Until now, more than 320 papers, including Nature (1), Science (2), Nature Chemistry (4), Nature Communications (2), Accounts of Chemical Research (6), Journal of the American Chemical Society (80), Angewandte Chemie International Edition (28), and Chemical Science (14), have been published in the fields of Bioinorganic and Biomimetic Chemistry.
Dioxygen is essential in life processes, and enzymes activate dioxygen to carry out a variety of biological reactions. One primary goal in biomimetic research is to elucidate structures of reactive intermediates and mechanistic details of dioxygen activation and oxygenation reactions occurring at the active sites of enzymes, by utilizing synthetic metal-oxygen complexes. A growing class of metal-oxygen complexes, such as metal–superoxo, –peroxo, –hydroperoxo, and –oxo species, have been isolated, characterized spectroscopically, and investigated in various oxygenation reactions.
During the past decade, we have been studying the chemical and physical properties of various reactive intermediates in oxygenation reactions, such as high-valent metal-oxo complexes of heme and non-heme ligands in oxo-transfer and C-H activation reactions, non-heme metal-peroxo complexes in nucleophilic reactions, and non-heme metal-superoxo complexes in electrophilic reactions. The effects of supporting and axial ligands on structural and spectroscopic properties and reactivities of metal-oxygen adducts have been extensively investigated as well.
In this presentation, I will present our recent results on the synthesis and structural and spectroscopic characterization of mononuclear nonheme metal-dioxygen intermediates as well as their reactivities in electrophilic and nucleophilic oxidation reactions.